Why the study?
The study was conducted to provide clinicopathologic and imaging features of primary angiosarcoma of the breast.
Observational (n=8)
No
Primary breast angiosarcoma is an extremely rare and aggressive tumor with a very poor prognosis, requiring immunohistochemistry for definitive diagnosis.
The aim of our study is to provide clinicopathologic and imaging features of breast primary angiosarcoma. We retrospectively analyzed cases of primary angiosarcoma diagnosed at the Pathological Laboratory of Lomé over a period of 20 years (2000-2019). Eight cases of primary angiosarcoma of the breast were collected, including 6 from women and 2 from men. The median age was 41.63 years (range from 17 to 66 years). Depending on the location, there were 4 of 8 cases in the left breast. Ultrasound classifications were BI-RADS 4 and 5. Histology revealed a malignant vascular proliferation composed of small lumens lined by atypical endothelial cells, evident mitoses, and foci of necrosis. On immunohistochemistry, the lesional cells expressed CD31, CD34, and Factor VIII. Based on Federation Nationale des Centers de Lutte Contre Le Cancer (FNCLCC) grading, the cases were grade II and III. Overall survival at 6 months was estimated to be 25% in a woman.
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Darré et al. (2022) conducted an observational in Primary angiosarcoma of the breast (n=8). Clinicopathologic and imaging characteristics was evaluated on Overall survival at 6 months.
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