Key result
Patients with secondary breast angiosarcoma presented with significantly less localized disease compared to those with primary breast angiosarcoma (48% vs 82%, P=0.003), with no difference in mortality.
Population
70 cases of breast angiosarcomas identified from the Florida Cancer Data System from 1981 to 2000.
Design
Cohort
Authors
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Secondary cases may warrant heightened post-radiation surveillance; this Level 3 cohort analysis leaves open biologic versus detection drivers of stage disparity.
Observational (n=70)
Yes
Absolute Event Rate: 48% vs 82%
p-value: p=0.003
Secondary breast angiosarcoma after breast-conserving therapy presents with more advanced disease compared to primary breast angiosarcoma, though mortality is similar.
Hodgson et al. (2007) conducted an observational in Breast angiosarcoma (n=70). Secondary breast angiosarcoma (prior irradiation) vs. Primary breast angiosarcoma was evaluated on Local disease at presentation (p=0.003). Patients with secondary breast angiosarcoma presented with significantly less localized disease compared to those with primary breast angiosarcoma (48% vs 82%, P=0.003), with no difference in mortality.
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