Key result
Diastolic blood pressure has a causal effect on neuroticism, with 1074 independent instrumental single nucleotide polymorphisms identified in Mendelian randomisation analyses.
Why the study?
High blood pressure is linked to psychological factors, but causal relationships with anxiety, depressive symptoms, neuroticism, and subjective well-being remain unclear.
Does genetic predisposition to high blood pressure causally affect anxiety, depressive symptoms, neuroticism, or subjective well-being?
Observational
Does genetic predisposition to high blood pressure causally affect anxiety, depressive symptoms, neuroticism, or subjective well-being?
Diastolic blood pressure has a genetic causal effect on neuroticism, suggesting that appropriate blood pressure management may help reduce neuroticism and related mood disorders.
Hypothesis-generating for DBP-neuroticism link; does not support changing BP management.
Background: High blood pressure is a leading cardiovascular disease risk factor and considered to be associated with psychological factors. However, the causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being are not clear. Aims: The current study explored the genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being. Methods: Mendelian randomisation (MR) analyses were performed using the generalised summary-data-based MR analysis method with eight large-scale genome-wide association study datasets for hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, anxiety, depressive symptoms, neuroticism and subjective well-being. Results: A causal effect of DBP on neuroticism was found, and 1074 independent instrumental single nucleotide polymorphisms were identified by the incorporated Heterogeneity in Dependent Instruments-outlier test among the bidirectional causal relationship between blood pressure and the four psychological states. Conclusions: DBP has a causal effect on neuroticism. Appropriate management of blood pressure may reduce neuroticism, neuroticism-inducing mood disorders and cardiovascular diseases.
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Cai et al. (2022) conducted an observational in Blood pressure and psychological states. Diastolic blood pressure was evaluated on Causal effect on neuroticism. Diastolic blood pressure has a causal effect on neuroticism, with 1074 independent instrumental single nucleotide polymorphisms identified in Mendelian randomisation analyses.
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