Key result
Genetically predicted high SBP linked to lower Alzheimer's disease risk in meta-analysis.
Why the study?
Findings from randomized controlled trials have yielded conflicting results on the association between blood pressure and dementia traits, motivating investigation of a causal relationship between blood pressure and Alzheimer's disease risk.
Does genetically predicted high blood pressure reduce the risk of Alzheimer's disease?
Observational (n=368,440)
Yes
Does genetically predicted high blood pressure reduce the risk of Alzheimer's disease?
Effect estimate: β -0.14
p-value: p=.03
Mendelian randomization analysis suggests a causal relationship between genetically predicted higher blood pressure and a reduced late-life risk of Alzheimer's disease.
No takes yet. Share an insight, caveat, or question.
May suggest higher BP protects against AD; hypothesis-generating and should not change practice without RCT confirmation.
Sproviero et al. (2020) conducted an observational in Alzheimer's disease (n=368,440). High blood pressure (systolic and diastolic) was evaluated on Alzheimer's disease (combined meta-analysis of diagnosis and family history) (β -0.14, p=.03). Genetically predicted high systolic blood pressure was causally associated with a reduced risk of Alzheimer's disease in a combined meta-analysis (β = -0.14, p = .03).
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