Why the study?
Epidemiological studies have shown a controversial correlation between blood pressure and dementia risk, hindering translation into preventative practice.
Does blood pressure level affect the risk of dementia and its subtypes in a dose-response manner?
Population
Participants across prospective studies evaluating all dementia, AD, and VD
Comparison
Varying levels of systolic and diastolic blood pressure
Design
Linear and non-linear dose-response meta-analysis of prospective studies
Authors
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Observational meta-analysis links BP to dementia subtypes; leaves open causal targets and need for RCTs before prevention changes.
Does blood pressure level affect the risk of dementia and its subtypes in a dose-response manner?
The relationship between blood pressure and dementia risk is nonlinear and varies by age, suggesting that BP management for dementia prevention should be tailored to specific population characteristics.
Wang et al. (2018) studied this question.