What does this research mean for the field?

In elderly individuals taking antihypertensive medication, there is an inverse association between blood pressure levels and the risk of developing dementia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 15, 2000Dementia and Geriatric Cognitive Disorders

Blood Pressure and Risk of Dementia: Results from the Rotterdam Study and the Gothenburg H-70 Study

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Why the study?

Is there an association between blood pressure levels and the risk of dementia in older adults?

Population

6,985 subjects from two prospective population-based studies

Comparison

Blood pressure levels (systolic and diastolic) vs Lower vs higher blood pressure levels

Design

Cohort

Follow-up

average 2.1 years

Authors

ARAnnemieke RuitenbergJohns Hopkins University ISIngmar SkoogReykjavík University AOAlewijn OttNational Institute for Public Health and the Environment

Discussion

Member takes

Implication

Higher BP linked to lower dementia risk in treated elderly; hypothesis-generating and should not yet alter targets pending trials.

Structured PICO

Is there an association between blood pressure levels and the risk of dementia in older adults?

Population

6,985 subjects from two prospective population-based studies (Rotterdam study, n=6,668, aged ≥55 years; Gothenburg H-70 Study, n=317, aged 85 years at baseline)

Intervention

Blood pressure levels (systolic and diastolic)

Comparator

Lower vs higher blood pressure levels

Outcome

Development of dementiahard clinical

In elderly persons on antihypertensive medication, higher blood pressure is associated with a decreased risk of dementia, suggesting a potential need for higher blood pressure to maintain cerebral perfusion or reflecting reverse causality.

Limitations

Potential reverse causality (lower blood pressure may be secondary to brain lesions in preclinical stages of dementia)

Cite This Study

Ruitenberg et al. (2000) studied this question.

synapsesocial.com/papers/6a1ba4530ea968f653ac0f19 https://doi.org/10.1159/000051233

Topics

Hypertension management

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Blood Pressure and Risk of Dementia: Results from the Rotterdam Study and the Gothenburg H-70 Study

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Blood Pressure and Risk of Dementia: Results from the Rotterdam Study and the Gothenburg H-70 Study

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider