Key result
Baseline systolic blood pressure ≥180 mm Hg was associated with an increased risk of incident dementia (RR 1.6) compared to systolic pressure of 141-160 mm Hg in adults aged 75 and older.
Why the study?
Does high systolic blood pressure or blood pressure reduction influence the incidence of dementia in non-demented persons aged 75+ years?
Cohort (n=1,270)
Does high systolic blood pressure or blood pressure reduction influence the incidence of dementia in non-demented persons aged 75+ years?
Relative Risk: 1.6
High systolic blood pressure is associated with an increased risk of dementia in older adults, while blood pressure reduction may be secondary to the dementia process itself.
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Very high SBP signals higher dementia risk in adults ≥75; leaves open whether BP lowering prevents dementia.
Guo et al. (2001) conducted a cohort in Dementia (n=1,270). High systolic blood pressure (≥180 mm Hg) vs. Systolic blood pressure 141-160 mm Hg was evaluated on Incidence of dementia (RR 1.6). Baseline systolic blood pressure ≥180 mm Hg was associated with an increased risk of incident dementia (RR 1.6) compared to systolic pressure of 141-160 mm Hg in adults aged 75 and older.
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