January 1, 2009Dementia and Geriatric Cognitive Disorders
Low Diastolic Pressure and Risk of Dementia in Very Old People: A Longitudinal Study
Key result
Low diastolic pressure (<70 mm Hg) was associated with an increased risk of dementia compared to 70-89 mm Hg (HR 2.13; 95% CI 1.05-4.32) among very old people.
Why the study?
Does low diastolic blood pressure increase the risk of dementia in very old people?
Population
422 dementia-free older adults aged ≥81 years
Comparison
Low diastolic blood pressure (<70 mm Hg) vs Normal diastolic blood pressure and high…
Design
Cohort
Follow-up
3 years
Authors
Discussion
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Implication
Should not yet alter BP targets in very old adults; leaves open whether low diastolic pressure contributes to dementia risk.
Study Design
Type
Cohort (n=422)
Structured PICO
Does low diastolic blood pressure increase the risk of dementia in very old people?
P
Population
422 dementia-free older adults aged ≥81 years followed for 3 years to detect incident dementia and Alzheimer's disease.
E
Exposure
Low diastolic blood pressure (<70 mm Hg)
C
Comparator
Normal diastolic blood pressure (70-89 mm Hg) and high diastolic blood pressure (≥90 mm Hg)
O
Outcome
Incident dementia and Alzheimer's disease (AD)hard clinical
Main Result
Hazard Ratio: 2.13 (95% CI 1.05–4.32)
Low diastolic blood pressure in very old adults is associated with an increased risk of developing dementia, with blood pressure declining substantially in the years preceding clinical diagnosis.
Cite This Study
Qiu et al. (2009) conducted a cohort in Dementia and Alzheimer's disease (n=422). Low diastolic pressure (<70 mm Hg) vs. Diastolic pressure 70-89 mm Hg was evaluated on Dementia (HR 2.13, 95% CI 1.05-4.32). Low diastolic pressure (<70 mm Hg) was associated with an increased risk of dementia compared to 70-89 mm Hg (HR 2.13; 95% CI 1.05-4.32) among very old people.