June 1, 1999Journal of the American Geriatrics Society
Low Blood Pressure and Incidence of Dementia in a Very Old Sample: Dependent on Initial Cognition
Why the study?
Does low baseline systolic blood pressure predict the incidence of dementia in very old nondemented subjects?
Population
304 nondemented subjects aged 75 to 96 years at baseline from the Kungsholmen district of Stockholm, Sweden.
Comparison
Baseline systolic blood pressure <= 140 mm Hg vs Baseline systolic blood pressure of 141 to 179…
Design
Cohort
Follow-up
average of 3 years
Authors
Discussion
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Member takes
Implication
Low SBP-dementia association in very old adults attenuates after cognitive adjustment; hypothesis-generating and should not yet change practice.
Structured PICO
Does low baseline systolic blood pressure predict the incidence of dementia in very old nondemented subjects?
P
Population
304 nondemented subjects aged 75 to 96 years at baseline from the Kungsholmen district of Stockholm, Sweden.
I
Intervention
Baseline systolic blood pressure <= 140 mm Hg
C
Comparator
Baseline systolic blood pressure of 141 to 179 mm Hg
O
Outcome
Incidence of dementiahard clinical
Low blood pressure in very old individuals may be an early correlate of a dementing process rather than an independent causative factor, as its association with incident dementia is dependent on initial cognitive status.
Cite This Study
Guo et al. (1999) studied this question.