June 15, 1997American Journal of Epidemiology
Blood Pressure and Performance on the Mini-Mental State Examination in the Very Old: Cross-sectional and Longitudinal Data from the Kungsholmen Project
Key result
In untreated adults aged 75-101 years, baseline systolic blood pressure <130 mmHg was associated with increased risk of cognitive impairment compared to 130-159 mmHg (OR 1.88; p=0.05).
Why the study?
Is blood pressure level associated with cognitive function and risk of cognitive impairment in the very old?
Population
1,736 people aged 75-101 years from a community-based Swedish cohort (Kungsholmen Project)
Comparison
Blood pressure levels (systolic and diastolic) vs Different blood pressure categories
Design
Cohort
Follow-up
average 40.5 months
Authors
Discussion
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Implication
Low SBP may warrant cognitive caution in untreated very old adults; hypothesis-generating for age-specific BP targets.
Study Design
Type
Cohort (n=1,736)
Structured PICO
Is blood pressure level associated with cognitive function and risk of cognitive impairment in the very old?
P
Population
1,736 community-dwelling Swedish adults aged 75-101 years, followed for an average of 40.5 months to assess the association between blood pressure and cognitive function.
E
Exposure
Blood pressure levels (systolic and diastolic)
C
Comparator
Different blood pressure categories (e.g., <130 mmHg vs 130-159 mmHg)
O
Outcome
Cognitive function assessed by Mini-Mental State Examination (MMSE) score and cognitive impairment (MMSE < 24)surrogate
Main Result
Odds Ratio: 1.88
p-value: p=0.05
In very old individuals, a systolic blood pressure of at least 130 mmHg may be important for maintaining cognitive function, while severe uncontrolled hypertension remains a risk.
Limitations
- Use of blood pressure measurements made at a single visit
- Relatively short follow-up period
- use of blood pressure measurements made at a single visit
- relatively short follow-up period
Cite This Study
Guo et al. (1997) conducted a cohort in Cognitive impairment (n=1,736). Baseline systolic blood pressure < 130 mmHg vs. Baseline systolic blood pressure 130-159 mmHg was evaluated on Follow-up cognitive impairment (MMSE score < 24) (OR 1.88, p=0.05). In untreated adults aged 75-101 years, baseline systolic blood pressure <130 mmHg was associated with increased risk of cognitive impairment compared to 130-159 mmHg (OR 1.88; p=0.05).