Blood pressure from mid‐ to late life and risk of incident dementia
Key result
Midlife systolic hypertension is linked to ~57% greater risk of incident dementia.
- HR 1.57
- 95% CI 1.05-2.35
- n=1,440
Why the study?
Do specific blood pressure patterns and trajectories from mid- to late life alter the risk of incident dementia in community-dwelling adults?
Population
1,440 Framingham Offspring participants free of dementia, mean age 69 ± 6 years at late life baseline, 758…
Comparison
Midlife hypertension, late life hypertension… vs Normotension or absence of the specific blood…
Design
Cohort
Follow-up
mean 8 years
Authors
Discussion
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Implication
Supports midlife BP monitoring for dementia risk; leaves open causal effects and intervention benefits in observational cohorts.
Study Design
Type
Cohort (n=1,440)
Structured PICO
Do specific blood pressure patterns and trajectories from mid- to late life alter the risk of incident dementia in community-dwelling adults?
P
Population
1,440 Framingham Offspring participants free of dementia, mean age 69 ± 6 years at late life baseline (mean age 55 years at midlife baseline), 758 women.
I
Intervention
Midlife hypertension (≥140/90 mm Hg), late life hypertension, lower late life blood pressure (<100/70 mm Hg), persistence of hypertension during mid- to late life, and steep decline in blood pressure from mid- to late life.
C
Comparator
Normotension or absence of the specific blood pressure patterns.
O
Outcome
Incident dementia over a mean 8 years of follow-up.
Main Result
Effect estimate: HR 1.57 (95% CI 1.05-2.35)
Persistent hypertension from midlife to late life, as well as a steep decline in blood pressure among nonhypertensives, are associated with an increased risk of incident dementia.
Cite This Study
McGrath et al. (2017) conducted a cohort in Dementia (n=1,440). Midlife systolic hypertension vs. Normotension was evaluated on Incident dementia (HR 1.57, 95% CI 1.05-2.35). Midlife systolic hypertension (HR 1.57; 95% CI 1.05-2.35) and its persistence into late life (HR 1.96; 95% CI 1.25-3.09) were associated with an elevated risk of incident dementia.