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August 1, 2025Age and Ageing

Blood pressure and all-cause mortality in dementia: a nationwide cohort study

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Authors

JYJung Eun YooKHKyungdo HanJJJin‐Hyung Jung

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Overview

Cohort study reveals reverse J-shaped link between blood pressure and mortality in dementia patients, suggesting implications for hypertension management.

Key Points

  • A reverse J-shaped association between systolic blood pressure and all-cause mortality was found in individuals with dementia.
  • Mean follow-up of 3.7 years revealed that 52,118 deaths occurred, highlighting a significant mortality rate in this population.
  • Cohort analysis included 146,832 new dementia diagnoses, assessing blood pressure's impact on mortality using Cox regression.
  • Managing blood pressure in dementia patients is crucial, as higher diastolic blood pressure significantly increases mortality risk.

Cite This Study

Yoo et al. (2025) studied this question.

synapsesocial.com/papers/68af63ddad7bf08b1eae4172https://doi.org/10.1093/ageing/afaf239
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Also Consider

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  5. 5Hypertension and Dementia: A Mendelian Randomisation Study Assessing Potential Causal Relationships with All-Cause Dementia, Alzheimer’s Disease and Vascular Dementia in the UK Biobank2025 · 2 citations