Animal study demonstrates enhanced new bone formation with PLLA membrane window closure in rabbits, indicating superior tissue regeneration.
BACKGROUND: When augmenting the maxillary sinus without grafting material, the method used to cover the bony window is a subject of debate. PURPOSE: The purpose of this study was to evaluate the poly-L-lactic acid (PLLA) membrane as closing material of the lateral window in a maxillary sinus augmentation without bone grafting. MATERIALS AND METHODS: Augmentation of the maxillary sinus without grafting material and installation of titanium screws that fix the Schneiderian membrane were performed in 18 Japanese male white rabbits. The bony window was covered with a collagen membrane or PLLA membrane or no membrane. The animals were sacrificed at 4 or 8 weeks. New bone volume was calculated radiologically using microcomputed tomography (micro-CT). The samples were analyzed histologically after toluidine blue staining. RESULTS: No significant differences were observed in the new bone volume, as measured by micro-CT. However, histomorphometric analysis demonstrated the superiority of the PLLA membrane in new bone formation compared with the collagen membrane. CONCLUSION: The PLLA membrane is a suitable material to be applied for tissue regeneration in this animal model.
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Kusumoto et al. (2015) studied this question.
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