Bromination of 2-Methyl-1,8-naphthyridine Derivatives

This paper reported the bromination of 2-methyl-1,8-naphthyridine derivatives. Monobrominated products, 2-bromomethyl-1,8-naphthyridine derivatives, and dibrominated byproducts were obtained with N-bromosuccimide(NBS) as the bromination agent under infrared light. Two synthetic conditions were evaluated. The yield of monobrominated products is up to 54.6% under the optimized condition of 2-methyl-1,8-naphthyrdine derivatives and NBS in molar ratio of 1∶1.2 under 500 W infrared light.