Key result
Laparoscopic Roux-en-Y gastric bypass led to the resolution of type 2 diabetes in 88.9% of morbidly obese patients within 12 weeks after surgery.
Why the study?
Does laparoscopic Roux-en-Y gastric bypass improve or resolve type 2 diabetes in morbidly obese patients?
Observational (n=73)
No
Does laparoscopic Roux-en-Y gastric bypass improve or resolve type 2 diabetes in morbidly obese patients?
Laparoscopic Roux-en-Y gastric bypass leads to a high rate of early type 2 diabetes resolution in morbidly obese patients, often occurring within weeks of surgery.
May support bypass for early T2D resolution in obesity; leaves open causality and durability pending RCTs.
BACKGROUND: The idea of surgery as treatment for type 2 diabetes mellitus (T2DM) was established in the US and was based on observation of patients after bariatric surgery. Resolution of T2DM is observed within a few weeks after surgery, in some cases even during hospitalization. The aim of this study was to evaluate the impact of Roux-en-Y gastric bypass (RYGB) on diabetes in morbidly obese patients. METHODS: We present 73 patients with T2DM who underwent laparoscopic RYGB (LRYGB) to treat morbid obesity. In the group of 73 obese patients (mean BMI = 42.3), there were 41 females and 32 males. RESULTS: Regression of T2DM was observed in 51 patients (69.8%) while hospitalized. In addition, 14 patients' (19.1%) glycemia and HBA1c stabilized within 12 weeks after surgery (total regression rate of 88.9%). CONCLUSION: The ultimate evaluation of this method of treating T2DM is still lacking and requires several years of meticulous clinical studies. Despite that, considering the high cost of life-long conservative therapy of T2DM and its complications and the severe impact T2DM has on quality of life, surgical metabolic intervention may become the most reasonable solution in many cases.
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Proczko‐Markuszewska et al. (2012) conducted an observational in Type 2 diabetes mellitus and morbid obesity (n=73). Laparoscopic Roux-en-Y gastric bypass (LRYGB) was evaluated on Resolution of type 2 diabetes mellitus (HbA1c <6% and fasting glucose <100 mg/dl) within 12 weeks. Laparoscopic Roux-en-Y gastric bypass led to the resolution of type 2 diabetes in 88.9% of morbidly obese patients within 12 weeks after surgery.
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