Why the study?
Does oxprenolol improve symptom reduction in patients with primary clinical anxiety compared to diazepam and placebo?
Does oxprenolol improve symptom reduction in patients with primary clinical anxiety compared to diazepam and placebo?
Diazepam is more effective and acts faster than the beta-blocker oxprenolol in treating primary clinical anxiety.
Favors diazepam over oxprenolol for primary anxiety; confirms benzodiazepine superiority in symptom reduction speed and efficacy.
An investigation of the effectiveness of the beta adrenoceptor blocking drug oxprenolol in the treatment of primary clinical anxiety is reported. A controlled double-blind evaluation of oxprenolol versus diazepam and placebo was carried out. The results of the trial showed diazepam to be generally more effective and to produce a more rapid onset of symptom reduction than oxprenolol. The role of beta adrenergic blocking drugs in the treatment of clinical anxiety and related syndromes is discussed.
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Johnson et al. (1962) studied this question.
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