Key result
Serum levels of ACE and Ang IIT1R were significantly higher in patients with newly diagnosed AML or ALL compared to healthy controls, and decreased significantly after therapy.
Why the study?
The renin-angiotensin system plays roles in cell proliferation and cancer, but its role has not been fully elucidated in patients with acute leukemia.
Do serum levels of ACE and Ang IIT1R have diagnostic and prognostic value in patients with acute leukemia?
Case-Control (n=60)
Do serum levels of ACE and Ang IIT1R have diagnostic and prognostic value in patients with acute leukemia?
Serum levels of ACE and Ang IIT1R are elevated in acute leukemia and decrease after therapy, suggesting potential diagnostic and prognostic value.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for ACE/Ang IIT1R as acute leukemia biomarkers; prospective validation needed before clinical adoption.
Ebied et al. (2018) conducted a case-control in Acute leukemia (AML and ALL) (n=60). Acute leukemia (AML and ALL) vs. Healthy volunteers was evaluated on Serum level of Angiotensin II receptor type 1 (Ang IIT1R) and soluble angiotensin converting enzyme (ACE). Serum levels of ACE and Ang IIT1R were significantly higher in patients with newly diagnosed AML or ALL compared to healthy controls, and decreased significantly after therapy.
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