Key result
Growth hormone decreases secretion of IL-1beta by macrophages, which in a paracrine manner increases adipocyte differentiation.
Population
J774A.1 macrophage cells, 3T3-L1 preadipocytes, and stromal vascular compartment macrophages from mice with…
Comparison
Growth hormone (GH) treatment vs Untreated macrophages and macrophages from…
Design
Preclinical
Authors
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Hypothesis-generating for GH effects on adiposity; human studies needed before clinical relevance.
Growth hormone decreases macrophage secretion of IL-1beta, thereby promoting adipocyte differentiation in a paracrine manner.
Lü et al. (2010) studied Adipogenesis. Growth Hormone (GH) vs. Control (untreated macrophages or GHR knockout mice) was evaluated on Adipocyte differentiation and IL-1beta expression. Growth hormone decreases secretion of IL-1beta by macrophages, which in a paracrine manner increases adipocyte differentiation.
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