What question did this study set out to answer?

To determine whether associative learning induces memory-specific changes in the spatial distribution and amount of protein kinase C within the CA1 field of the hippocampus.

August 25, 1989Science

Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus

View Full Paper

Ask AI

Bookmark

Authors

JOJohn OldsGeorge Mason University MAMatthew L. AndersonUniversity of South Florida DMDonna L. McPhieMcLean Hospital

Discussion

Member takes

Overview

Experimental study demonstrates spatial redistribution of hippocampal protein kinase C in classically conditioned rabbits, indicating dynamic molecular shifts during memory consolidation.

Key Points

To determine whether associative learning induces memory-specific changes in the spatial distribution and amount of protein kinase C within the CA1 field of the hippocampus.
Subjected rabbits to classical conditioning of the nictitating membrane as an associative learning paradigm.
Generated computer-analyzed coronal autoradiographs using [3H]phorbol-12,13-dibutyrate binding to map PKC localization in hippocampal CA1 at 1 and 3 days post-training.
Focal increments of [3H]phorbol-12,13-dibutyrate binding to PKC were detected specifically in the CA1 cell field at 1 day after learning.
Autoradiographic signals revealed a redistribution of PKC within the CA1 region from neuronal somas to dendrites at 3 days post-conditioning.

Cite This Study

Olds et al. (1989) studied this question.

synapsesocial.com/papers/6a987fc2a9ce68495d3df553 https://doi.org/10.1126/science.2772638

View Full Paper

Ask AI

Bookmark

August 25, 1989Science

Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus

View Full Paper

Ask AI

Bookmark

Authors

JOJohn OldsGeorge Mason University MAMatthew L. AndersonUniversity of South Florida DMDonna L. McPhieMcLean Hospital

Discussion

Member takes

Overview

Experimental study demonstrates spatial redistribution of hippocampal protein kinase C in classically conditioned rabbits, indicating dynamic molecular shifts during memory consolidation.

Key Points

To determine whether associative learning induces memory-specific changes in the spatial distribution and amount of protein kinase C within the CA1 field of the hippocampus.
Subjected rabbits to classical conditioning of the nictitating membrane as an associative learning paradigm.
Generated computer-analyzed coronal autoradiographs using [3H]phorbol-12,13-dibutyrate binding to map PKC localization in hippocampal CA1 at 1 and 3 days post-training.
Focal increments of [3H]phorbol-12,13-dibutyrate binding to PKC were detected specifically in the CA1 cell field at 1 day after learning.
Autoradiographic signals revealed a redistribution of PKC within the CA1 region from neuronal somas to dendrites at 3 days post-conditioning.

Cite This Study

Olds et al. (1989) studied this question.

synapsesocial.com/papers/6a987fc2a9ce68495d3df553 https://doi.org/10.1126/science.2772638

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark