January 1, 1985Journal of Medical Virology
Treatment of chronic non‐A, non‐B hepatitis with acyclovir: Pilot study
Why the study?
Does acyclovir improve clinical or biochemical outcomes in patients with chronic non-A, non-B hepatitis?
Population
5 patients with chronic non-A, non-B hepatitis
Design
Case_series
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
Acyclovir shows no benefit in this series; leaves open antiviral efficacy in chronic non-A, non-B hepatitis.
Structured PICO
Does acyclovir improve clinical or biochemical outcomes in patients with chronic non-A, non-B hepatitis?
P
Population
5 patients with chronic non-A, non-B hepatitis
I
Intervention
Acyclovir by slow intravenous infusion 5 mg/kg every 8 hr for 10 days (two patients received a second course at 10 mg/kg every 8 hr for 10 days)
O
Outcome
Serum aminotransferase levels and clinical or serum biochemical improvementsurrogate
A short course of intravenous acyclovir does not provide long-term clinical or biochemical benefits in patients with chronic non-A, non-B hepatitis.
Cite This Study
Pappas et al. (1985) studied this question.