Key result
Prostaglandin E2 promoted cardiac fibrosis in cultured adult rat cardiac fibroblasts by upregulating pro-fibrotic proteins and inducing calcium influx via the EP1 receptor.
Why the study?
Does Prostaglandin E2 promote cardiac fibrosis via the EP1 receptor and calcium signal pathway in cultured adult rat cardiac fibroblasts?
Population
Cultured adult rat cardiac fibroblasts (CFs)
Design
Preclinical
Authors
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May support EP1 blockade to limit cardiac fibrosis; leaves open translation from rat cell culture to in vivo models.
Does Prostaglandin E2 promote cardiac fibrosis via the EP1 receptor and calcium signal pathway in cultured adult rat cardiac fibroblasts?
p-value: p=<0.05
PGE2 promotes cardiac fibrosis through the EP1 receptor and calcium signaling pathway in rat cardiac fibroblasts, identifying a potential mechanistic target for cardiac fibrosis.
Ma et al. (2018) studied Cardiac fibrosis. Prostaglandin E2 (PGE2) vs. Vehicle control was evaluated on Expression of α-SMA, CTGF, FN, and Collagen I, and [Ca2+]i increase (p=<0.05). Prostaglandin E2 promoted cardiac fibrosis in cultured adult rat cardiac fibroblasts by upregulating pro-fibrotic proteins and inducing calcium influx via the EP1 receptor.
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