Why the study?
Does calcium administration after reperfusion improve the recovery of systolic and diastolic function in stunned myocardium?
Does calcium administration after reperfusion improve the recovery of systolic and diastolic function in stunned myocardium?
While calcium administration during ischemia or early reperfusion is deleterious, its administration after reperfusion may enhance the functional recovery of stunned myocardium.
Timing of calcium may modulate stunned myocardium recovery; hypothesis-generating and requires randomized trials before clinical consideration.
Calcium administration during ischemia or at the onset of reperfusion is generally considered to be deleterious because cytosolic calcium is elevated at this time. In contrast, the administration of calcium antagonists before or during ischemia is protective. While calcium antagonists may not be beneficial when given after reperfusion, calcium administration during this period has been found to enhance the recovery of systolic and diastolic function of stunned myocardium.
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C. David Mazer (1993) studied this question.
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