Key result
Prophylactic dabigatran etexilate following total hip replacement resulted in a fatal massive gastrointestinal hemorrhage in 1 patient (a 79-year-old woman) due to the lack of a reversal agent.
Case Report (n=1)
This case highlights the fatal consequences of dabigatran-induced gastrointestinal haemorrhage due to the lack of a reversal agent.
Emphasizes fatal bleed risk without reversal for dabigatran post-THR in elderly; leaves open safer perioperative anticoagulation options.
We report a fatality due to massive gastrointestinal haemorrhage in a patient receiving prophylactic dabigatran etexilate following a total hip replacement. A 79-year-old woman was commenced on dabigatran for venous thromboembolic prophylaxis following a total hip replacement. She presented again four days after surgery with haematemesis and hypotension but her coagulopathy could not be corrected, leading to her death. This case highlights the lack of reversal agent for dabigatran etexilate that resulted in this fatal complication.
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Carter et al. (2014) conducted a case report in Total hip replacement (n=1). Dabigatran etexilate was evaluated on Fatality due to massive gastrointestinal haemorrhage. Prophylactic dabigatran etexilate following total hip replacement resulted in a fatal massive gastrointestinal hemorrhage in 1 patient (a 79-year-old woman) due to the lack of a reversal agent.
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