Key result
The acetate/propionate ratio significantly discriminated young adults with acute myocardial infarction from healthy controls (AUC 0.769, P < 0.0001).
Why the study?
Microbial-derived metabolites modulate inflammation with potential implications for cardiovascular diseases, but their serological alterations in young acute myocardial infarction patients remained to be evaluated.
Observational (n=45)
Effect estimate: AUC 0.769
p-value: p=< 0.0001
Young adults with acute myocardial infarction exhibit significant imbalances in gut microbiota-derived metabolites, particularly the acetate/propionate ratio, which correlates with inflammatory and coagulation parameters.
Acetate/propionate ratio may aid AMI identification in young adults; leaves open causal role and clinical utility pending prospective trials.
Acute myocardial infarction (AMI) is associated with systemic inflammatory processes and metabolic alterations. Microbial-derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide (TMAO), have emerged in recent years as key players in the modulation of inflammation, with potential implications for cardiovascular diseases. We performed a prospective observational study that monitored the serological concentration of bacterial metabolites in 45 young patients (<55 years) without cardiovascular risk factors but with AMI, at hospital admission and at 3 months of follow-up, and compared them with a control group. TMAO and acetate levels were significantly higher in AMI, whereas butyrate and propionate were significantly lower. The acetate/propionate ratio showed the most discrimination between AMI and controls by receiver operating characteristic analysis (area under the curve 0.769, P < 0.0001). A multivariate logistic regression model revealed that this ratio was independently associated with AMI. Short-chain fatty acid concentrations, but not TMAO, exhibited significant correlations with inflammatory and coagulation parameters. Three months after the acute AMI event, all metabolite levels returned to those observed in healthy controls except butyrate. In conclusion, our study reveals disturbances of the serological concentration of microbiota-derived metabolites in AMI that are also related to inflammatory and coagulation parameters. These findings highlight an interesting field of study in the potential role of microbial metabolites from gut in cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Avendaño‐Ortiz et al. (2023) conducted an observational in Acute myocardial infarction (n=45). Acute myocardial infarction vs. Healthy controls was evaluated on Discrimination between AMI and controls by acetate/propionate ratio (AUC 0.769, p=< 0.0001). The acetate/propionate ratio significantly discriminated young adults with acute myocardial infarction from healthy controls (AUC 0.769, P < 0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: