Answers are grounded in this paper and cite their sources.
Using the laser dye rhodamine 123, we demonstrated that local anaesthetics can reach mitochondria in cell culture and reversibly decrease, or even collapse, their transmembrane potential. This effect is highly dependent on the lipid-solubility of the local anaesthetic and can be facilitated by the presence of a lipophilic anion.
No takes yet. Share an insight, caveat, or question.
Grouselle et al. (1990) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: