This preclinical study maps the genomic site responsible for the cardiovirulent phenotype of coxsackievirus B3, which is implicated in inflammatory heart disease and dilated cardiomyopathy.
The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent (able to cause disease). Here, we present preliminary data mapping the site in a coxsackievirus B3 genome which determines a cardiovirulent phenotype.
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Tracy et al. (1995) studied this question.
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