Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval
Key result
Common and rare genetic variants, including 11 novel loci and rare variants at MYH6 and SCN5A, were significantly associated with the electrocardiographic PR interval (P<1.2x10^-6).
Population
92,803 participants (83,367 of European ancestry and 9,436 of African ancestry)
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
May inform genetic risk models for conduction disorders; extends the PR interval GWAS catalog with novel and rare loci.
Study Design
Type
Meta-Analysis (n=92,803)
Structured PICO
P
Population
92,803 participants of European and African ancestry evaluated for genetic variants associated with the PR interval.
E
Exposure
Common and rare genetic variants
O
Outcome
PR intervalsurrogate
Main Result
p-value: p=<1.2x10^-6
The identification of 11 novel common genetic loci and rare variants in MYH6 and SCN5A associated with the PR interval provides new insights into the genetic basis of atrioventricular conduction.
Cite This Study
Lin et al. (2018) conducted a meta-analysis in Electrocardiographic PR Interval (n=92,803). Common and rare genetic variants was evaluated on Association with PR interval (p=<1.2x10^-6). Common and rare genetic variants, including 11 novel loci and rare variants at MYH6 and SCN5A, were significantly associated with the electrocardiographic PR interval (P<1.2x10^-6).