Key result
A genome-wide association meta-analysis in 13,415 African American adults identified a novel locus, ITGA9, associated with PR interval (P<5.0 × 10(-8)).
Population
13,415 adults of African descent from 10 cohorts
Design
Meta-analysis
Authors
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Novel PR loci mapped in African Americans; extends prior GWAS and leaves open clinical utility for conduction risk.
Meta-Analysis (n=13,415)
Yes
p-value: p=<5.0 × 10(-8)
This genome-wide association study in African Americans identified a novel genetic locus (ITGA9) associated with the PR interval and confirmed several loci previously found in European and Asian populations.
Butler et al. (2012) conducted a meta-analysis in PR interval (n=13,415). Single-nucleotide polymorphisms was evaluated on PR interval (ms) (p=<5.0 × 10(-8)). A genome-wide association meta-analysis in 13,415 African American adults identified a novel locus, ITGA9, associated with PR interval (P<5.0 × 10(-8)).
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