Key result
Genetic variants, such as rs174547, showed significant associations with obesity in the Malaysian population across 35 reviewed studies.
Why the study?
Obesity is a pressing public health issue in Malaysia, requiring comprehensive strategies including an understanding of population-level differences in obesity susceptibility.
What genetic variants are associated with obesity in the Malaysian population?
What genetic variants are associated with obesity in the Malaysian population?
This scoping review highlights the need for population-based genetic profiling to understand obesity susceptibility in Malaysia and develop targeted interventions.
May inform ethnicity-specific obesity risk profiling in Malaysia; extends global genetic associations but remains hypothesis-generating pending validation.
BACKGROUND: Obesity is a pressing public health issue in Malaysia, involving not only excess weight but also complex metabolic and physiological changes. Addressing these complexities requires comprehensive strategies, including understanding the population-level differences in obesity susceptibility. This review aims to compile the genetic variants studied among Malaysians and emphasize their implications for obesity risk. METHODS: Relevant articles published up to March 2024 were extracted from the Scopus, PubMed, and ScienceDirect databases. The review process was conducted in accordance with the PRISMA-ScR guidelines. From an initial pool of 579 articles, 35 of these were selected for the final review. RESULTS: (rs174547-Indian only), showed significant associations with obesity as measured by the respective studies. CONCLUSIONS: Overall, more intensive genetic research is needed, starting with population-based profiling of genetic data on obesity, including among children. Sociocultural contexts and environmental factors influence variations in genetic elements, highlighting the need for targeted interventions to mitigate the impacts of obesity in the population.
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Hamzah et al. (2024) conducted a review in Obesity (n=35). Genetic variants was evaluated on Association with obesity. Genetic variants, such as rs174547, showed significant associations with obesity in the Malaysian population across 35 reviewed studies.
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