Two steps forward: The glycosylated aminocoumarin antibiotic novobiocin (1) is produced by Streptomyces spheroides and inhibits the bacterial type II topoisomerase DNA gyrase. The sugar-tailoring enzymes NovP and NovN that catalyze the final two steps in novobiocin biosynthesis were overproduced in Escherichia coli and characterized as a methyltransferase and carbamoyltransferase, respectively.
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Meyers et al. (2003) studied this question.
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