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The first asymmetric total synthesis of the natural pyrrole lactone longanlactone has been achieved. The key reactions, a Barbier propargylation and a Paal–Knorr pyrrole synthesis, have provided easy access to the target natural product from L‐aspartic acid in six steps and 31 % overall yield. The C‐4 epimer of the natural product and propionyllonganlactone have also been prepared by this strategy.
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Reddy et al. (2014) studied this question.
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