Key result
An 8-year-old boy with parameningeal rhabdomyosarcoma developed a massive right atrial metastasis that initially showed a 70% partial response to salvage chemotherapy but ultimately progressed.
Case Report (n=1)
Cardiac metastases should be considered in the differential diagnosis for thoracic symptoms in pediatric patients treated for soft tissue sarcomas, as they can be clinically silent or misattributed to pulmonary metastases.
An eight-year-old boy treated for a local recurrence of a stage IV parameningeal rhabdomyosarcoma complains four months after a second complete response, from dyspnea, chest pain and cyanosis. Imagery showed a bulky pleuro-mediastinal lesion. Echocardiography revealed a massive right atrial mass suggestive of metastasis. A partial response (70%) was obtained after four courses of chemotherapy, but progression was observed after ten cycles of chemotherapy and patient died one month later. This case of incidentally diagnosed heart metastases is particular because it occurred in a child and the primary tumor was a parameningeal rhabdomyosarcoma.
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Imtinane et al. (2018) conducted a case report in Parameningeal Rhabdomyosarcoma with cardiac metastasis (n=1). Salvage chemotherapy (ifosfamide and vinorelbine) was evaluated on Tumor response. An 8-year-old boy with parameningeal rhabdomyosarcoma developed a massive right atrial metastasis that initially showed a 70% partial response to salvage chemotherapy but ultimately progressed.
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