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August 22, 2026Child s Nervous SystemOpen Access

Multimodal therapy halts metastatic growth and shrinks lesions at 6 weeks in a cardiac sarcoma case.

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Population

An 18-year-old Hispanic male with primary cardiac sarcoma, intracranial metastasis, and embolic infarction

Design

Case report

Follow-up

Six-week

Key result

Multimodal treatment including surgery, radiosurgery, and chemotherapy led to no new metastatic growth and reduced lesion size at 6-week follow-up in an 18-year-old with primary cardiac sarcoma.

Authors

MSMason T. StoltzfusJHJinpyo HongTHThaddeus Harbaugh

Discussion

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Overview

May inform multimodal strategies for rare cardiac sarcoma CNS spread; extends case data but leaves open need for prospective validation.

Key Points

  • To describe the clinical course, diagnosis, and multimodal management of an aggressive primary cardiac sarcoma presenting with central nervous system metastases and embolic infarction.
  • Clinical and radiological evaluation of an 18-year-old male presenting with progressive headaches, nausea, and diplopia.
  • Staged multimodal intervention consisting of initial craniotomy, sternotomy for cardiac tumor resection and left atrial reconstruction, repeat craniotomy for rapid recurrence, hypofractionated Gamma Knife radiosurgery, and systemic chemotherapy.
  • Initial craniotomy resolved symptoms, but one-month surveillance showed a primary left atrial mass, intracranial embolic infarcts, and a 6-cm local tumor recurrence causing midline shift.
  • Following gross-total re-resection of the brain metastasis, radiosurgery, and chemotherapy, 6-week follow-up imaging confirmed tumor reduction and no new metastatic growth.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
An 18-year-old male with a large left atrial cardiac sarcoma and multiple intracranial lesions treated with multimodal surgical and medical therapy.
I
Intervention
Multimodal therapy including repeat craniotomy for brain metastasis resection, sternotomy for primary cardiac sarcoma resection and left atrial reconstruction, hypofractionated Gamma Knife radiosurgery, and chemotherapy
O
Outcome
Response to treatment assessed by imagingsurrogate

This case highlights the aggressive nature of primary cardiac sarcoma and the necessity of multimodal, repeat surgical intervention for CNS involvement.

Limitations

  • Single case report limits generalizability
  • Short follow-up duration

Cite This Study

Stoltzfus et al. (2026) conducted a case report in Primary cardiac sarcoma with intracranial metastasis and embolic infarction (n=1). Multimodal therapy (surgery, radiosurgery, chemotherapy) was evaluated on Clinical and radiographic response. Multimodal treatment including surgery, radiosurgery, and chemotherapy led to no new metastatic growth and reduced lesion size at 6-week follow-up in an 18-year-old with primary cardiac sarcoma.

synapsesocial.com/papers/6a895ed9ca7ade938187cf50https://doi.org/10.1007/s00381-026-07434-2
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