Why the study?
Does aspirin inhibit prostacyclin synthesis in cultured rat aorta smooth muscle cells?
Population
Monolayer cultures of rat aorta smooth muscle cells
Design
Preclinical
Follow-up
up to 24 hours
Authors
Loading...
May blunt thrombin-stimulated prostacyclin in quiescent vascular cells; leaves open recovery mechanisms in vivo.
Does aspirin inhibit prostacyclin synthesis in cultured rat aorta smooth muscle cells?
Aspirin permanently impairs thrombin-stimulated prostacyclin synthesis in resting vascular smooth muscle cells, requiring cell division for full recovery.
Whiting et al. (1980) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: