Key result
Tramadol significantly improved brachial flow-mediated dilation at 2 hours postoperatively compared to placebo (6.7% vs. 6.0%, P=0.001) in patients undergoing laparoscopic cholecystectomy.
Why the study?
Does postoperative analgesic therapy with intravenous tramadol improve arterial endothelial function in patients undergoing non-cardiac surgery?
Population
160 adults undergoing laparoscopic cholecystectomy with standardized total intravenous anesthesia. Mean age…
Comparison
Tramadol intravenous patient-controlled… vs 0.9% saline administered postoperatively. Both…
Design
RCT, 1:1 ratio using software-driven randomization, double-blind…
Follow-up
5 days
Authors
Loading...
Tramadol attenuates postoperative endothelial dysfunction in non-cardiac surgery; extends opioid vascular effects to the perioperative RCT setting.
RCT (n=160)
Double-blind
software-driven
No
Does postoperative analgesic therapy with intravenous tramadol improve arterial endothelial function in patients undergoing non-cardiac surgery?
Absolute Event Rate: 6.7% vs 6%
p-value: p=0.001
Effective postoperative pain control with tramadol significantly attenuates the decline in arterial endothelial function following non-cardiac surgery, potentially reducing the risk of perioperative myocardial injury.
Wu et al. (2017) conducted an RCT in Endothelial dysfunction following non-cardiac surgery (n=160). Tramadol vs. Saline (placebo) was evaluated on Brachial endothelium-dependent flow-mediated dilation (FMD) at 2 hours postoperatively (p=0.001). Tramadol significantly improved brachial flow-mediated dilation at 2 hours postoperatively compared to placebo (6.7% vs. 6.0%, P=0.001) in patients undergoing laparoscopic cholecystectomy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: