Key result
A 52-year-old diabetic female developed recurrent deep venous thrombosis and venous gangrene due to cholangiocarcinoma, highlighting that non-diabetic causes of gangrene must be considered in diabetics.
Case Report (n=1)
Highlights the importance of considering non-diabetic causes of gangrene, such as phlegmasia caerulia dolens due to malignancy, in diabetic patients.
May warrant malignancy evaluation in diabetics with atypical venous gangrene; single case leaves open broader applicability.
A 52 year old diabetic female with obstructive jaundice due to cholangiocarcinoma developed recurrent deep venous thrombosis and venous gangrene (phlegmasia caerulia dolens). Carcinomatosis is the usual underlying cause of this rare form of gangrene and has a high mortality. It is important to remember that diabetic subjects can develop ‘non‐diabetic’ gangrene, and other causes should be considered depending upon the clinical presentation.
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Gandhi et al. (2002) conducted a case report in Venous gangrene (phlegmasia caerulia dolens) and recurrent deep venous thrombosis (n=1). Cholangiocarcinoma was evaluated on Development of recurrent deep venous thrombosis and venous gangrene. A 52-year-old diabetic female developed recurrent deep venous thrombosis and venous gangrene due to cholangiocarcinoma, highlighting that non-diabetic causes of gangrene must be considered in diabetics.
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