This case highlights that squamous cell carcinoma of the lung can rarely present as bilateral venous gangrene with negative anticardiolipin antibodies.
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Bilateral venous gangrene may rarely indicate lung squamous cell carcinoma despite negative antibodies; single case leaves open need for confirmatory studies.
Bilateral venous thrombosis due to underlying malignancy is a rare entity. It is worthy to search for malignancy in patients of bilateral venous gangrene. Our patient presented with severe bilateral leg pain as a result of venous gangrene. There was associated left sided massive pleural effusion with scalp nodule. Fine needle aspiration cytology of scalp nodule revealed metastatic squamous cell carcinoma and fiber optic bronchoscopy guided biopsy from growth at left upper lobe bronchus confirmed the case as squamous cell carcinoma lung. It was rare for squamous cell carcinoma lung to present as bilateral venous gangrene with anticardiolipin antibody negative.
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Saha et al. (2013) studied this question.
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