Key result
Increasing tertiles of serum osteoprotegerin levels were independently associated with high arterial stiffness in hemodialysis patients, with the highest tertile having an OR of 7.06.
Why the study?
Cardiovascular morbidity and mortality are prevalent in end-stage renal disease, and osteoprotegerin may link bone loss to vascular calcification, but its relationship with central arterial stiffness in hemodialysis patients required evaluation.
Is serum osteoprotegerin associated with central arterial stiffness in hemodialysis patients?
Cross-Sectional (n=120)
No
Is serum osteoprotegerin associated with central arterial stiffness in hemodialysis patients?
Odds Ratio: 7.06 (95% CI 2.03–24.49)
p-value: p=0.002
Serum osteoprotegerin levels are independently associated with central arterial stiffness in hemodialysis patients, suggesting a potential link between bone loss markers and vascular calcification.
May inform vascular risk assessment in hemodialysis; leaves open whether osteoprotegerin measurement improves outcomes or warrants intervention.
BACKGROUND: Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels in hemodialysis (HD) patients. METHODS: Blood samples were collected from 120 HD patients, and the carotid-femoral pulse wave velocity (cfPWV) value was measured using a validated tonometry system. The cfPWV value of > 10 m/s was used to define the high artery stiffness group. Serum OPG levels were analyzed categorically into tertiles. RESULTS: Of the 120 HD patients, 53 (44.2%) were defined as the high arterial stiffness group, who had higher values of systolic blood pressure (p = 0.038), serum calcium (p = 0.007), and OPG (p < 0.001) levels and a higher prevalence of diabetes mellitus (DM, p = 0.001). Increasing tertiles of serum OPG levels were significantly associated with greater height (p = 0.011), male gender (p = 0.008), higher cfPWV values (p = 0.020), and lower intact parathyroid hormone (iPTH, p = 0.049) levels. Multivariable linear regression analysis showed that cfPWV value was independently associated with DM (β = 1.83, p = 0.008) and increasing tertiles of serum OPG levels (β = 0.89 and 1.63 for tertile 2 and tertile 3, respectively, p for trend = 0.035) in HD patients. Multivariable logistic regression analysis revealed that, in addition to age, DM, low iPTH levels, and high serum calcium levels, increasing tertiles of serum OPG levels (OR = 5.34 for tertile 2; OR = 7.06 for tertile 3; p for trend = 0.002) were an independent predictor of high arterial stiffness in HD patients. Serum calcium levels positively correlated with cfPWV value only in the highest OPG tertile group (r = 0.408, p = 0.009). CONCLUSION: A positive association was detected between serum OPG levels and central arterial stiffness in HD patients, and patients with high serum OPG levels may have greater influence of calcium load on central arterial stiffening.
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Hou et al. (2019) conducted a cross-sectional in Hemodialysis (n=120). Serum osteoprotegerin (OPG) levels vs. Lower tertiles of serum OPG levels was evaluated on High arterial stiffness (cfPWV > 10 m/s) (OR 7.06, 95% CI 2.03-24.49, p=0.002). Increasing tertiles of serum osteoprotegerin levels were independently associated with high arterial stiffness in hemodialysis patients, with the highest tertile having an OR of 7.06.
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