Excretion of Adrenaline and Noradrenaline in Human Subjects*

The pressor substance in normal human urine demonstrated by Holtz et al. (1) was considered by them to be a mixture of adrenaline, noradrenaline and hydroxytyramine. A few years later Von Euler ect al. (2, 3) succeeded in separating all three amines from urine extracts by the use of chromatographic techniques. In a preceding paper (4) we reported observations regarding the nature of the adrenaline and noradrenaline in normal human urine. The present report concerns experiments which were conducted to determine the excretion of adrenaline (A) and noradrenaline (NA): 1) in sleep and in waking states; 2) after the infusion of A and NA into an adrenalectomized subject; 3) after psychomotor stress, operating the Hoagland-Werthessen pursuitmeter (5) under normal and hypoxic conditions; and 4) after the administration of ACTH.