Key result
Relative residence time (RRT) showed the highest spatial correlation (ρ = 0.71) with fatty streak prevalence in the right coronary artery, explaining approximately half of its anatomical variation.
Why the study?
Coronary artery disease is clinically significant, but comparing atherosclerosis distribution with haemodynamic wall shear stress metrics is complicated by vessel motion during the cardiac cycle.
Observational (n=1,862)
No
Answers are grounded in this paper and cite their sources.
Relative residence time, reflecting low wall shear stress and highly multidirectional flow, accounts for approximately half of the anatomical variation in early atherosclerotic lesion prevalence in the right coronary artery.
PURPOSE: The patchy anatomical distribution of atherosclerosis has been attributed to variation in haemodynamic wall shear stress (WSS). The consensus is that low WSS and a high Oscillatory Shear Index (OSI) trigger the disease. We found that atherosclerosis at aortic branch sites correlates threefold better with transverse WSS (transWSS), a metric which quantifies multidirectional near-wall flow. Coronary artery disease has greater clinical significance than aortic disease but computation of WSS metrics is complicated by the substantial vessel motion occurring during each cardiac cycle. Here we present the first comparison of the distribution of atherosclerosis with WSS metrics computed for moving coronary arteries. METHODS: Maps of WSS metrics were computed using dynamic geometries reconstructed from angiograms of ten non-stenosed human right coronary arteries (RCAs). They were compared with maps of fatty streak prevalence derived from a previous study of 1852 RCAs. RESULTS: Time average WSS (TAWSS), OSI, transWSS and the cross-flow index (CFI), a non-dimensional form of the transWSS, gave non-significant or significant but low spatial correlations with lesion prevalence. The highest correlation coefficient (0.71) was for the relative residence time (RRT), a metric that decreases with TAWSS and increases with OSI. The coefficient was not changed if RRT was calculated using CFI, which captures multidirectional WSS only, rather than OSI, which encompasses both multidirectional and oscillatory WSS. CONCLUSION: Contrary to our earlier findings in the aorta, low WSS in combination with highly multidirectional flow correlates best with lesion location in the RCA, explaining approximately half of its anatomical variation.
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Kandangwa et al. (2024) conducted an observational in Atherosclerosis (n=1,862). Relative Residence Time (RRT) and Wall Shear Stress (WSS) metrics was evaluated on Spatial correlation (Spearman's ρ) between relative residence time (RRT) and fatty streak prevalence (ρ 0.71, 95% CI 0.51-0.72). Relative residence time (RRT) showed the highest spatial correlation (ρ = 0.71) with fatty streak prevalence in the right coronary artery, explaining approximately half of its anatomical variation.
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