August 19, 2014ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Change of Direction in the Biomechanics of Atherosclerosis

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Atherosclerosis (n=17). Intervention: Transverse wall shear stress (transWSS) vs. Time average wall shear stress (TAWSS) and Oscillatory shear index (OSI). Primary outcome: Correlation between lesion prevalence and transWSS around aortic branch ostia.

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Key result

Transverse wall shear stress, an index of multidirectional flow, correlated positively and significantly with atherosclerotic lesion prevalence in both immature and mature rabbit aortas.

Why the study?

Does multidirectional flow (transWSS) correlate better with atherosclerotic lesion prevalence than oscillatory shear index (OSI) in rabbit aortas?

Study Design

Type

Observational (n=17)

Structured PICO

Does multidirectional flow (transWSS) correlate better with atherosclerotic lesion prevalence than oscillatory shear index (OSI) in rabbit aortas?

Population

17 male New Zealand White rabbits (8 immature, 9 mature) fed a 1% cholesterol diet for 8 weeks to study the correlation between aortic lipid deposition and hemodynamic wall shear stress.

Exposure

Computational fluid dynamics mapping of transverse wall shear stress (transWSS) to characterize multidirectional flow.

Comparator

Other shear metrics including time average wall shear stress (TAWSS) and oscillatory shear index (OSI).

Outcome

Correlation between lesion prevalence and wall shear stress metrics (transWSS, TAWSS, OSI) around intercostal branch ostia.surrogate

Multidirectional near-wall flow (transWSS) correlates significantly better with atherosclerotic lesion prevalence than low, oscillatory shear stress, challenging traditional biomechanical theories of atherogenesis.

Limitations

The mature pattern of lesions has varied slightly from study to study
The boundary conditions used in the numerical simulations are approximations
Only described results for a small region around branch ostia
Have not yet investigated a range of other shear metrics
Mature pattern of lesions varied slightly between studies
Boundary conditions in numerical simulations are approximations
Only a small region around branch ostia was described
Other shear metrics not yet investigated

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not change clinical practice; leaves open human relevance while challenging OSI-centric atherogenesis models in animals.

Cite This Study

Mohamied et al. (2014) conducted an observational in Atherosclerosis (n=17). Transverse wall shear stress (transWSS) vs. Time average wall shear stress (TAWSS) and Oscillatory shear index (OSI) was evaluated on Correlation between lesion prevalence and transWSS around aortic branch ostia. Transverse wall shear stress, an index of multidirectional flow, correlated positively and significantly with atherosclerotic lesion prevalence in both immature and mature rabbit aortas.

synapsesocial.com/papers/6a22e6a646d2b2b483f2e1b4 https://doi.org/10.1007/s10439-014-1095-4

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Change of Direction in the Biomechanics of Atherosclerosis

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Change of Direction in the Biomechanics of Atherosclerosis

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider