Key result
Actin cross-linkers made the length distribution of tread-milling actin filaments inside bundles narrower compared to free filaments in a kinetic model.
A kinetic model demonstrates that actin cross-linkers narrow the length distribution of tread-milling actin filaments inside bundles compared to free filaments.
May inform cytoskeletal models in cardiomyocytes; leaves open in vivo validation for cardiac actin regulation.
The length distribution of tread-milling actin filaments has been measured in vitro , in the presence of severing and cross-linking proteins. The cross-linking proteins induce the formation of bundles, and we present here a kinetic model for this system which takes into account the inherent asymmetry and non-equilibrium nature of the tread-milling actin filaments. The effects of actin cross-linkers is to make the length distribution of filaments inside bundles narrower compared to free filaments. We get good agreement with the available experimental data.
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Nir S. Gov (2007) studied this question. Actin cross-linkers vs. Free filaments was evaluated on Length distribution of filaments. Actin cross-linkers made the length distribution of tread-milling actin filaments inside bundles narrower compared to free filaments in a kinetic model.
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