Bio-pharmaceutical industries face an increasing demand to accelerate process development and reduce costs. This challenge requires high throughput tools to replace the traditional combination of shake flasks and small-scale stirred tank bioreactors. A conventional and widely used process development tool is the stirred tank reactor (STR) ranging from approximately 1L to 10L in working volume. Physical culture parameters such as pH, temperature and pO 2 can be easily controlled in such systems.
No takes yet. Share an insight, caveat, or question.
Delouvroy et al. (2013) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: