Mediastinal irradiation for Hodgkin's disease can lead to severe, premature atherosclerotic coronary artery disease.
May signal isolated coronary atherosclerosis after mediastinal radiation; hypothesis-generating for targeted surveillance in Hodgkin survivors.
Summary: Radiation‐related coronary artery disease in Hodgkin's disease. A. S. Y. Leong, I. J. Forbes and T. Ruzic, Aust. N.Z. J. Med., 1979, 9, pp. 423–425. Coronary artery disease is a rare and only recently recognised complication of mediastinal irradiation. A 34‐year‐old man died suddenly eight years after mediastinal irradiation for Hodgkin's disease. Autopsy disclosed severe narrowing of all major extramural coronary arteries by atherosclerotic plaques whereas all other systemic and visceral arteries were virtually free of atheroma. Autopsy findings in the five reported cases of radiation‐related coronary artery disease are reviewed.
No takes yet. Share an insight, caveat, or question.
Leong et al. (1979) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: