Background: Although coronary calcium assessment has been demonstrated to be strongly associated with significant coronary artery disease (CAD) and future cardiac events, it is still not clear whether zero calcium on CT scan can exclude significant CAD and eliminate the need for further multi-detector computed tomography (MDCT) coronary angiography (CCTA). The purpose of this study is to test the hypothesis that zero coronary calcium on MDCT does not exclude significant CAD and CCTA is required to exclude CAD in diverse populations who have a zero calcium score.
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Jarreau et al. (2010) studied this question.
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