April 1, 1997AJP Heart and Circulatory Physiology
Infarct size reduction with the nucleoside transport inhibitor R-75231 in swine
Why the study?
Does the nucleoside transport inhibitor R-75231 reduce infarct size in a swine model of myocardial ischemia and reperfusion?
Population
Pentobarbital-anesthetized swine undergoing 60 min of coronary artery occlusion and 2 h of reperfusion (n=24)
Comparison
R-75231 administered 15 min before either… vs Control pigs (n=8)
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Pre-ischemic R-75231 timing matters in swine; leaves open translation of adenosine-mediated cardioprotection to human ischemia-reperfusion injury.
Structured PICO
Does the nucleoside transport inhibitor R-75231 reduce infarct size in a swine model of myocardial ischemia and reperfusion?
P
Population
Pentobarbital-anesthetized swine undergoing 60 min of coronary artery occlusion and 2 h of reperfusion (n=24)
I
Intervention
R-75231 (0.1 mg/kg i.v.) administered 15 min before either coronary occlusion (n=8) or reperfusion (n=8)
C
Comparator
Control pigs (n=8)
O
Outcome
Infarct size (% of the region at risk)surrogate
The nucleoside transport inhibitor R-75231 reduces myocardial infarct size in a swine model only when administered prior to ischemia, likely by augmenting interstitial adenosine levels.
Cite This Study
Martin et al. (1997) studied this question.