Why the study?
Does bilateral surgical renal denervation restore the diuretic and natriuretic effects of ANP in rats with chronic ischaemic heart failure?
Does bilateral surgical renal denervation restore the diuretic and natriuretic effects of ANP in rats with chronic ischaemic heart failure?
In experimental ischaemic heart failure, renal denervation reverses the blunted renal excretory response to ANP, suggesting a functional antagonism between efferent renal sympathetic nerve activity and ANP.
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Renal denervation effects remain experimental in heart failure; leaves open sympathetic-ANP interactions for human translation.
Pettersson et al. (1989) studied this question.
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