Key result
A single dose of tulathromycin significantly increased markers of oxidative stress, including malondialdehyde and nitric oxide, and decreased antithrombin III levels in rabbits (P < 0.05).
Why the study?
Does tulathromycin affect serum oxidative status and coagulation factors in rabbits?
Does tulathromycin affect serum oxidative status and coagulation factors in rabbits?
Tulathromycin administration in rabbits causes oxidative stress, decreases antithrombin III, and transiently increases CK-MB, suggesting potential cardiotoxicity and coagulation disturbances.
Answers are grounded in this paper and cite their sources.
Tulathromycin was associated with oxidative stress and reduced antithrombin III in rabbits; leaves open cardiotoxicity risk and needs validation before any clinical extrapolation.
The aim of this study was to determine the effect of tulathromycin on serum oxidative status and coagulation factors in rabbits. Tulathromycin was administered to eight rabbits, and blood samples were obtained 0, 1, 5, 10 and 15 days after treatment. Indicators of serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol and β-carotene) and coagulation values (antithrombin III, fibrinogen) were measured after tulathromycin treatment. In addition, routine serum biochemical values (creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high density lipoprotein, amylase, total protein, albumin, glucose and calcium), haemacell counts (white and red blood cells) and arterial blood gas parameters (packed cell volume, hemoglobin, pH, partial pressure of carbon dioxide, partial pressure of oxygen, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, sodium and potassium) were also determined. Tulathromycin increased (P < 0.05) the levels of malondialdehyde, nitric oxide and superoxide dismutase activity, and decreased (P < 0.05) the level of antithrombin III. In conclusion, tulathromycin may cause oxidative damage and coagulation disorders during the treatment period.
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Ayse et al. (2011) studied Healthy (n=8). Tulathromycin vs. Baseline (Day 0) was evaluated on Serum malondialdehyde (MDA) level at day 5 (mM) (p=<0.05). A single dose of tulathromycin significantly increased markers of oxidative stress, including malondialdehyde and nitric oxide, and decreased antithrombin III levels in rabbits (P < 0.05).
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