ParaproteinsParaproteins typically appear as narrow bands after electrophoresis.Thanks to the concepts of Waldenstrom and Burnet and the fundamental work on immunoglobulin structure of Porter and others (reviewed by Hobbs 1966) there is now good support for the hypothesis that paraproteins are monoclonal immunoglobulins, and recently Marchalonis & Nossal (1968) showed that the antibody produced by a single cell indeed ran as a narrow band on electrophoresis.
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J R Hobbs (1969) studied this question.
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