Key result
Histological examination of a painless submucosal nodule on the upper lip of a 40-year-old man revealed angiolymphoid hyperplasia with eosinophilia, an extremely rare presentation in the oral mucosa.
Case Report (n=1)
This case report highlights a rare presentation of angiolymphoid hyperplasia with eosinophilia involving the oral mucosa.
Consider ALHE in differentials for painless submucosal lip nodules; extends sparse oral reports but leaves broader characterization open.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare. We report a case and review the literature of ALHE cases involving the oral mucosa. A 40-year-old man presented with a painless, 20 x 20 mm, submucosal nodule on the upper lip. Histological examination of lip biopsy specimens revealed an increase in many small vessels. The vascular walls consisted of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.
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Suzuki et al. (2005) conducted a case report in Angiolymphoid hyperplasia with eosinophilia (ALHE) (n=1). Lip biopsy was evaluated on Histological diagnosis. Histological examination of a painless submucosal nodule on the upper lip of a 40-year-old man revealed angiolymphoid hyperplasia with eosinophilia, an extremely rare presentation in the oral mucosa.
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